Hey, I'm Latif Nasser. Today, I'm going to play you an old episode that I reported way back in 2015. It's got science, it's got miracles, it's got Vikings, it's got a potentially hazardous kitchen experiment performed by Senior Producer Matt Kielte and I. What I really love about this episode is how it makes you see progress not as a straight line, sometimes not even as a line at all. Sometimes it's actually a circle. I swear it'll make sense at the end of the episode. I now present to you, Staff Retreat. Wait, you're listening? Okay.

All right. You're listening to Radiolab.

Radiolab.

From W-N-Y-C. Rewind. Hey, I'm Chad Abramrod.

I'm Robert Crollwich.

This is Radiolab.

And today? Well, today, Yes. The story of an axe-wielding nun coming through a window to smack some Staphylococcus and take you back to the future.

Exactly.

The story comes- Does that make any sense? I don't know. Well, it will. Okay, it will.

The story comes in two parts, both from our producer, Latif Nasser, and here is part one.

The way the story goes, it starts in 1928.

1928. Alexander Fleming, the story goes, who knows if it's apocryphal or not, is growing staff Staphylococcus in his lab.

That's Maren McCana, she's a science writer, and Staphy is a bacterium.

It lives on our skin, and it especially likes parts of the body that are warm and damp.

It likes to be just up our noses or-In our genitals or in our armpits, places like that. And generally, it's no big deal. It doesn't really do us any harm. But if it gets into a scratch or a cut and makes its way inside our bodies-Staphy goes from being this benign companion to being potentially deadly. Anyway, London, 1928.

Fleming is growing staff in his lab.

In these little petri dishes, and he He was a slob, basically. He goes on a vacation, leaves his petri dishes, covered in bacteria, just around, leaves his window open.

Something blows across his lab plate.

Some tiny little speck of a thing just floats in through the window and comes to a rest on one of those petri dishes.

A few weeks later-Fleming, finally back from vacation. He needs to use those lab plates again, and he and his assistant go to clean them off.

I mean, you'd imagine that he would see some real, lush, nice, furry lawn of staff just overflowing right out of the plate. Because it's been sitting there for so long. It's been a staff party.

But on one of the plates that they pick up, they realize that it's almost polka-dent. It's got little dead zones all over it.

Little patches where the staff is dead.

Dead patches. So something blew through the The window landed in the dish and starts killing the bacteria.

Yeah, and so when Fleming looks down at his plate, he sees that at the center of these staff dead zones, there's a tiny speck of natural mold mold.

A mold. They realize that that mold is expressing a compound that is killing the staff around it.

It's like emanating rays of death. What was the compound? That compound was called… Penicillin. The first true antibiotic.

Infectious diseases that had been killing people for as long as we had been people suddenly could be stopped.

It just blew in through the window?

That is the story that's always been told.

However it got there, it was It was amazing. It was a miracle.

It was called a miracle drug, right?

It really was a moment when the world changed, when Fleming was put on the cover of Time magazine.

This was 1944, height of World War II.

It was a picture of his face and the banner on the cover said, His penicillin will save more lives than war can spend.

But, and this This is, I had no idea about this, virtually at the exact same time when Fleming's face is on the cover of Time magazine, like two months later, this Stanford researcher publishes that he has found five different strains of staph that do not respond to penicillin. Really? Yeah.

This is happening while he's on the cover?

Virtually the exact same moment.

It's the first sign that staph has responded to the penicillin in the world by developing resistance.

It's almost like a-Separdise or Soren Wheeler. The era of penicillin was over before it began.

Almost before it began.

Before it's even released to the general public.

Wow. That penicillin resistant staff moves across the globe.

In 1957, in Cleveland, some scientists gather together.

They are in a panic. They have no idea why they've lost the antibiotic miracle so quickly.

So scientists across the globe put their brains together and try to come up with a new drug.

The next amazing thing.

And in 1960, they get it.

Methicillin.

And it works.

For about 11 months.

Eleven months? Wow.

And so we started this arms race.

There was a bug, and then there was a drug that took care of it, and then there was a better bug.

Drug bug, drug bug.

Right, exactly. I actually found this list. Do you want to hear it? Yeah. Okay, so streptomycin, 1943, resistance, 1948. Methicillin, 1960, resistance, 1961. Clindamycin, 1969, resistance, 1970.

You can think of it as sleep frog, or you can think of it as a game of Whac-A-Mole.

Ampicillin, 1961, then 1973. So that's a little... Carbenicillin, released, 1969, resistance, 1974.

They're getting better. They're getting better.

There were always more drugs. The drug development was doing really well for a really long time.

Hypericillin, introduced 1980, Resistence 1981.

But after the year 2000, drug companies begin to realize it's not really in their best interest to make antibiotics anymore.

The end I have on this list is Linuzolid, which is introduced 2000, resistance 2002. There are a few more, but you get the idea.

Antibiotic approvals, the entry of new drugs to the market, just fell off a cliff. Why? Well, it takes 10 years and a billion dollars to get to the point where the drug is marketable.

But as soon as you get the drug on the market- The resistance The block is running. So you probably won't make your money back. As you've probably heard, we now have these situations. Well, frightening new warning from the centers for Disease Control about the spread of a string of germs-where literally nothing works.so-called super bugs are now turning up in hospitals-And the patient dies. There are now bugs that can resist all of our drugs.

I have seen physicians break down weeping over this. It's not the way that medicine is supposed to fail anymore, but it does.

I know that possibly the origin story of Penicillin is apocryphal, so this is all a little suspect, but just to enjoy imaginings for a moment, it just seems like if that happened, let's just open up a bunch more windows. Just something ought to blow in.

But we could wait a long time, right? I mean, staff had been around for millennia before 1928.

But the whole reason that I wanted to do this story is because there is a new window. It's a different window, though.

It's not a window next to some Petri dishes?

Not a window next to some Petri dishes. Kind of a window next to some Petri dishes, but a totally different window. What window is it? Well, I'm about to tell you that. Is something blowing to the window? Yeah, but it's not mold. It's way more fun than mold. It carries an ax. How about that? So it's a person? Maybe. I don't even know what I'm referring to anymore.

Radiolab is supported by better help. Whether it's already 2:00 AM on a fun night out, graduation time, a new year, we can find ourselves wishing we had more time, wondering where it all went. But There's a question. If we were magically given that time back, what would we do with it? Perhaps you'd spend more time with a friend that you've lost touch with, or petting your dog, or just noticing the sweetness of doing nothing. The best way to let those special things into your life is to know what's important to you so that you can make it a priority going forward. A therapist can guide you through the process of defining your values and understanding your priorities so you know what things you can spend your time on that will really fulfill you. Betterhelp offers convenient, affordable online therapy that comes to you. Start the process in minutes and switch therapists anytime. Learn how to make time for what makes you happy with Betterhelp. Visit betterhelp. Com/radiolab today to get 10% off your first month. That's betterhelp, h-e-l-p. Com/ radioLab.

Everybody's got a story about a piece of music.

I thought this is the greatest thing I've ever heard.

It's about pure experience, pure connection, pure joy.

This song allowed me to survive.

I'm Terrence McKnight with a new season of The Open Ears Project. Every Monday in under 20 minutes, you'll hear a different guest share their story. You can start your week on the right note. Listen wherever you get podcasts Part 2?

Yeah.

Okay. Hey, I'm Jadai Boomrad. I'm Robert Krollwich. This is Radiolab.

We're ready now for part 2. Now, remember when part 1 ended, there was a window open and something was going to come through. We don't know what. We know it's not mold. Yeah, we know it's not mold. So whatever it is, whatever it was, whatever it will be, we will hear about it now from our reporter, Latif Nasser.

Well, actually, there is this story about these two women who did open a window to an alien and distant land. Actually, in a way, it's a story about reimagining the past. But to me, it's a story about a friendship. Hey, everybody.

Hello, again.

Hello, again.

It's a story about an unlikely friendship. It's a buddy film. Yeah, it's a buddy movie. Okay, so maybe just walk us through it. Right. Okay, so you have- Hello, I'm Dr.

Christina Lee. Christina. I'm an Associate Professor in Viking Studies at the School of English at the University of Nottingham.

She's a historian. Then you also have- Hi, I'm Freya Harrison.

Freya. I'm a research fellow in the Center for Biomolecular Sciences at the University of Nottingham.

Freya is a microbiologist. She studies bacteria. We'll start with her.

Okay. Most of my work is about looking at how bacteria evolve during very, very long-lived infections. But my big hobby is Anglo-Saxon Viking reenactment. I had purely amateur interest in the history and mainly in dressing up as a warrior and going to fight club every Wednesday night and learning to use the weapons. This is actually not Freya's group.

This is a group in New Jersey, but basically they do the same thing. Hundreds of people go out into some field with some dulled weapons.

Everything from swords, spears, axes, and We give each other a jolly good bashing and have a good time.

I only mention this because it actually plays into the story.

It was a really nice coincidence, really.

2012. A few years after finishing her doctorate, Freya goes off to work at the University of Nottingham.

Nottingham is one of the places in the UK, not only for microbiology, but for Anglo-saxon and Viking history.

She goes there to study microbes, but she figures, Hey, why not while I'm here, brush up on my old English?

. I'd studied some old English to a level where I could read and speak a little bit. But she figured, Hey, she could be better.

And if she did, she would get deeper into the whole reenactment thing.

So I rather cheekily emailed the School of English's Old English reading group.

That's where she met Christina, the historian. At one point, Christina, the historian, asks What do you do? And Freya said, My day job is that I'm a microbiologist, but on evenings and weekends, I'm a history nerd. And Christina said, The moment she heard that-I just thought, I found my kindred spirit here. Because she was like, Wow, I'm like your mirror image because I'm a historian by day, but by night, I'm a microbiology nerd.

I've been interested in infectious disease for quite a long time, which I don't find any friends in my department.

She told me she's the person who would watch Ebola coverage on the news and not be able to stop watching. Eventually, they start talking about historical diseases. How would people back then have treated something like Ebola? Freya is especially interested in this because she, for her historical reenactment, is developing this nun character who goes off and heals people. But anyway, so they're talking back and forth, and then to cut a long story short, they find themselves both interested in this one particular book.

It's known as Bald's Leech Book. This is about 1100 years old.

What's it called? Bold's what?

Bold's Leach Book. It's nothing to do with no hair. Oh, Even though it just felt the same.

Is it B-A-L-D?

It is indeed.

And leech, like a leech, like a little worm that grabs onto your blood?

No, it comes from the old English word leche, which is actually a healer or a doctor.

So the little squiggly animals are called leaches because they're medicinal, not the other way around.

So the doctor wasn't named for the leech. The leech was named for the doctor.

Exactly.

Yeah. And bald is a man, the guy who wrote the book?

We think it's a guy. We think it's a guy's name.

And what is this book?

It's like this old healer's handbook. It's filled with these potions and cures.

The original manuscript is in the British library. Locked away.

But 21st century, very kind people have digitized the original old English text and put it online.

So Christina and Freya bring it up, and they start going through all the remedies.

It describes to you remedies for stuff that is a little bit different.

Things like...

Thone devil, thone manana.

Possession by the devil.

Which, according to In each book, the remedy for someone who is possessed by the devil is you- Spew a drink, el lutzre. Make this fowel brew. You make them drink it, and it'll make them vomit out the devil. Then there's another remedy for warts. Bishéob,. All I'm going to say about that one is that it involves hounds urine and mouse blood.

Then things like-if man se'a torana. How should we say, make your husband more physically attentive or less physically attentive, whichever direction you need to moderate it.

Pig's blood, I hope, or toad blood.

Drink on neakt nestia. Actually, it's just you boil a plant in some water and give it to the guy. Yeah. Anyway, So Fray and Christina are going through this leach book, looking for some wound.

Something that was clearly an infection.

Some pussy something.

We could clearly say that's bacterial.

And eventually, they find an entry Where at the end of the recipe, it says in Old English, Sebesta Latchdom.

Sebesta Latchdom, the best medicine.

The best medicine. Yeah, move over laughter.

Yeah. And we thought, How can we not try this one?

What was the best medicine for?

So it said it was for a lump in the eye.

It's actually called wen in the Old English.

Yeah. These days, if you get a... Of course, that could be something like a wart, right?

But there is a suggestion by archeologist that eye infection was rife amongst the Anglo-Saxons because you lived in buildings where you had smoke going on. You lived cramped together.

So it could also be a stye. What is a stye? It's an infection of an eyelash follicle.

You rub it and it itches and then it gets swollen.

It causes quite a nasty red lump.

It's a stye in your eye.

Stye in your eye. Now, it just so happens that the bacteria that causes the stye in your eye is Staphylococcus aureus.

Staphylococcus aureus. Staphylococcus aureus.

Oh, the same stuff as the Mr. Window Man, Penicillin Man.

Exactly.

We just thought, wouldn't it be nice to have a bit of spare time and a couple of hundred quid to buy the ingredients and just give this a go? Yes, let's give it a try. Why the hell not?

Matter of fact, Look at this place. We thought that, too. Studio. Not bad at all. Recently, producer Matt Kielte and I went to my tiny apartment in the city, and we tried to cook it up, too. Are you ready to cook? Oh, I'm ready to cook.

I've got this recipe here if you'd like it.

Oh, awesome. Yeah, please read it. Go for it.

Okay. It goes like this..

That's the first line of the recipe. Right off the bat for Christina and Freya, there's a problem. That first ingredient.

The word cropleach.

Cropleach.

Christina said it was quite difficult to translate.

Nobody quite knows what it is.

But luckily, just a couple words over was a clue.

And garlic. The second ingredient.

Garlic, which is an allium species. And cropleach.

We know this was another allium.

That's what the Dictionary of Old English tells us.

So they figured probably what they were dealing with was an onion or a leek.

But we didn't know which one. So we thought, okay, we'll try one that has onion and one that has leek.

. Now, Now, the recipe doesn't cover this, but we did it anyway. Peel the onion, chop it up. The same for the garlic.

And the recipe, it doesn't tell you how much. It does tell you equal amounts of.

So you take out the measuring cups, you measure out equal amounts. Yeah, equal amounts. Into the pestle. And then after that. Okay, it says...

A canoe war well... To be...

To somne. Pounded well together. Okay.

To be really pounded. And pounded for a day.

Yeah, so lots of time with the water on pestle. Muscles built up from wielding a sword for pounding the ingredient.

Look, it's starting to be more of a mush. Third ingredient?

The next one was definitely something you wouldn't have knocking around in your kitchen.

And feares.

Ox gall.

Ox gall.

Bovine bile from a cow's gall bladder.

What do you do? Do you have to kill the cow and then go reach it?

No, it's actually a very standard ingredient in microbiology labs.

Ox bile. Today in 2015, You can but should not just buy it on the internet. Here we go. Here we go. And so you take the oxbile, add it to the onion and garlic.

And then the fourth ingredient.

Ye name a ween. Wine. It's wine time. Red wine, white wine. What wine are we talking about here?

This is the thing. We had quite a discussion about what type of wine should we use? We don't know, really, did they have red wine? Did they have white wine? What was the alcohol content? But I did a bit of detective work.

She figured out that the monetary where this leach book was written, she figured out where their vineyard was.

Just down road, there's this modern organic vineyard.

So they used that wine.. I just want to point out how difficult it is to find English wine. We had to use Italian. But once you get all that stuff together, you're under the final ingredient.

The fifth ingredient was actually that you're specifically told that you have to mix these ingredients together in a brass or a bronze pot. I don't have one. So we had to add pieces of a bit of copper that would have been available to people at the time.

They had to do some research, but they figured out that the copper of today, that is most like the copper of a millennium ago, was actually-Cartridge brass, which is what's used as standard in plumbing fittings. Drop a few pennies in there. We actually use pennies. Do I stir it? I think I stir it. This is like a world's worst cooking show.

It looks and smells like quite a nice summer soup.

Oh, it looks awful. Oh, that's so gross. Clearly, we bot this whole thing.

.

Finally-so we're going to cover it. Okay, we're covering it. The directions say we have to let the whole thing sit for a while.

It has to be stored for nine days and nights. Okay, that's it.

One day goes by two days, three, four, five, six, seven, eight, nine.

All right. Nine days later.

All right, here we go. You ready? Mm-hmm. All right, here we go.

Then you have to strain it through a cloth.

The liquid that comes off, you apply to the person's eye.

Oh, the liquid. Yeah, With a feather.

With a feather.

Say, Bethsda Latchado. Now, clearly, we didn't have any staff to try this out on, but Freya, in her lab, she made these mock wounds.

With these little plugs of collagen. It's a bit like jelly.

Basically, it's a goopy substance made to be a flesh wound.

We infect these wounds with bacteria with the staff.

Then they put this 1,000-year-old recipe that had been standing there for nine days. They put it on the bacteria that was in the fake wound.

Obviously, we didn't think this was going to work. No. We thought, well, given the ingredients, we might see some small killing effect on the bacteria, but it won't be anything to write home about.

They thought maybe it'd kill 10%, 20% of the bacteria. But then when they came back the next day, It was a staff massacre. It went on a rampage. It went on a staff rampage.

It was killing 99.9999% of these bacterial cells. What? Yeah. First, we thought we made some mistake, and this was some fluke. We'd accidentally mixed up our plates or mislabeled something.

So they run the entire experiment again. They grab the ingredients, mash them up, put them on some bacteria, and it happens again.

Just absolutely wiped out the bacteria in these plate wounds. Kill them dead.

Then they tried a third time and a fourth and a fifth, and it works every time.

This is just something you really don't see in your career as a microbiologist.

And eventually, they escalated from just regular staff to MRSA, to the methacillin-resistant staff. This is one of the bad ones. A super bug.

New government data estimate that about 2,000 people are dying of community-based MRSA every year.

This one is very dangerous. Christina and Freya, they sent some of bald's brew to one of their collaborators in the States.

Our collaborator, Kendra Rimbaud in Lubuk, in Texas.

Kendra took the stuff, put it on some MRSA Then a week later, sent Freya and Christina an email.

I think it was actually a three-word response. I think she just simply said, What the fuck? What the fuck?

Bald's best medicine had just reaped It was like, havoc on the mursa. It killed 90% of them.

This is beyond our wildest dreams.

Now, Fray and Christina made very clear that this is not yet a miracle drug. I mean, it's not even being tested in humans.

So absolutely Do not do this at home.

They don't even know if this is safe.

It might be that if you don't do it in exactly the way we did, nasty fungus could grow in it, give you a worse infection.

We should not have done this. Matt and I, we dumped our stay on the drain. But the thing about this whole story that is so intriguing and so cool to me is this time travel thing, which is so strange. It's like the idea that something a thousand years ago, like a bullet forged a thousand years ago, we could use it now and then it could work. The time travel dimension of that is so weird to me. It makes you think differently about, I don't know, progress.

Without much further ado, Dr.

Christina Lee and Dr.

Freya Harrison, and they're going to talk to us about some ancient biotics.

For example, just a few weeks ago, Freya and Christina got up in front of the Royal Society of Chemists.

Thank you very much, and it is an absolute pleasure to be here.

Large hotel conference room, 100 or so people. Freya actually got up on stage dressed as a nun.

Okay, so this is one interpretation of what an Anglo-Saxon science may have looked like.

And they presented the results.

Next ingredient is particularly- They did the cooking demo.

And then at some point, Christina said something really interesting. She was like, Okay, sure. We want to write this off because it has demons and dragons and elves in it. But are we sure that we know what they meant by those words? For example- There are remedies which ask you sing for Avariez. And we would say, Oh, that's so superstitious. This is all in their heads.

But there again, we should also remember, this is a period when people do not have watches. You do not have your nurse, so that's got the watch. Everybody knows the Avaria. Everybody knows the length of an Avaria.

So maybe it's take this medicine and wait 20 minutes, and I know how to standardize 20 minutes, which is- Three avomarias, four Avarias may actually be time- That's fascinating. It may appear one way, and it, in fact, could be a totally different way. It suggests that in order to time travel, you have to somehow...

God, it's like we don't even have the language to be able to understand what they were doing and how effective it was.

There's a phrase, The past is a foreign country.

We need to learn the language of the doctors of time. We need to be a little bit less dismissive and learn a little bit more stuff from them. I learned a bit of humility this way.

But here's the reason why this is so confusing to me. So 1,100 years is a crazy long time for humans, and for bacteria, that's an exponentially crazy long time. So how is it that something The thing that this man, bald, was doing to these bacteria then, it's not even the same bacteria. How could that even work?

That's an awesome question. So one thing we've got to think about is, well, why did these medicines drop out of use? Maybe it's because when they were used, the bacteria evolved resistance. But now, a thousand years later, when these medicines have not been used, you would expect that resistance to be lost.

This is something that Maren McKenna mentioned to Soren and I, that sometimes when you take a drug out of circulation- Sometimes resistance will decline.

That doesn't always work, but sometimes resistance does decline. If we had been using this compound through the ensuing thousand years, then maybe it wouldn't work.

There's an interesting discovery there, that what worked once and then was resisted, you give it a rest and it can work again, and it will be resisted. And you put it to rest. And if you had enough different, if you could go to different places in the different paths, did you go to China, where they now got all these people studying Chinese cures and Arab cures, you could come up with a rich historical cocktail of armamentariums that will work. If you bring them in, take them out, bring them in, take them out. And the whole world, the whole world of the past, then becomes the fruit of your future, So it's also like now I have suddenly an image that it's possible that- This is Soren Wheeler, by the way, in conversation with Marion McKenna Latif.

That a thousand years ago, these folks went through what we went through with penicillin, in that this guy wrote something in the book, and it's actually called The Best Medicine. He probably got on the cover of whatever their version of time was.

He got their Nobel Prize.

And everybody celebrated. And then years later, Sties were coming back and the garlic wine didn't work anymore, and they stopped using it, and it got put away. And then here we are and we discover it, and it's been put away long enough that... Now I'm thinking about some future civilization digs up an old medical textbook that was in some dusty whatever and discovers penicillin. It works. Did I lose you on that, Mary?

No, I'm still with you. I don't know. It just seemed like such a great hypothetical construction. I just didn't really know what I could add to it. Sorry, I took over.

Thank you for listening.

It's actually been almost a full decade since we aird this episode. Since then, Christina and Freya have published several papers to show how this concoction works and why. Apparently, there's not just one, but multiple key ingredients at work in their ancient salves. They've also been collaborating with PhD students to create a recipe that can be turned into an actual medicine available to folks like you and me. But science is a slow process, and things like logistics and funding just make it even slower. They are pretty hopeful that they will get something to us before the next 1,000 years pass by.

Producer, Latif Nasser, with help from Soren Wheeler, and produced by Matthew Kielte. Special thanks this hour to Steve Diggle.

And to Alexander Ryder Justin Park, who came down from Yale to be our old English readers.

To Jean Morrow from the Gotham early music scene.

And to Marsha Young on the medieval harp.

Karl Monroe of Tadkaster.

And the rest of the Barony of Iron bog.

Not totally sure what that is, but I know they helped us out. I guess we should help ourselves Out.

Yes, very quickly.

Of the door or through the window. I'm Jad Abamrod.

I'm Robert Krillowich.

Thanks for listening.

Hi, I'm Elana, and I'm from Queens, New York.

Radiolab was created by Chad Abamrod and is edited by Soren Wheeler.

Lulu Miller and Latif Nasser are our co-hosts.

Dylan Keef is our Director of Sand Design.

Our staff includes Simon Adler, Jermy Bloom, Becker Bresler, Katie Foster-Kies, W. Harry Fortuna, David Gable, Maria Paz Gutierrez, Cindy Nianes-Sumbundam, Matt Kielte, Annie McEwen, Alex Niesen, Sara Khari, Sarah Sandback, Arianne Wack, Pat Walters, and Molly Webster. Our fact checkers are Diane Kelly, Emily Krieger, and Natalie Middleton.

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